{"id":47202,"date":"2021-08-12T17:05:42","date_gmt":"2021-08-12T22:05:42","guid":{"rendered":"https:\/\/everybrainmatters.org\/reintoxicacion-de-thc\/"},"modified":"2025-10-21T09:10:45","modified_gmt":"2025-10-21T14:10:45","slug":"reintoxicacion-de-thc","status":"publish","type":"page","link":"https:\/\/everybrainmatters.org\/es\/reintoxicacion-de-thc\/","title":{"rendered":"Reintoxicaci\u00f3n de THC"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Reintoxicaci\u00f3n: la liberaci\u00f3n de tetrahidrocannabinol (THC) almacenado en grasa en la sangre es<br\/>potenciada por la privaci\u00f3n de alimentos o la exposici\u00f3n a ACTH D9 -tetrahidrocannabinol (THC) en la sangre es potenciada por la privaci\u00f3n de alimentos o la exposici\u00f3n a ACTH<\/h4>\n\n<p><strong>Antecedentes y objetivo<\/strong>: El D9-tetrahidrocannabinol (THC), principal componente psicoactivo del cannabis, se acumula en el tejido adiposo, donde se almacena durante largos periodos de tiempo. Aqu\u00ed investigamos si las condiciones que promueven la lip\u00f3lisis pueden liberar THC de los adipocitos para producir un aumento de los niveles sangu\u00edneos de THC. <br\/><strong>Enfoque experimental<\/strong>: En los estudios in vitro se utilizaron adipocitos de rata reci\u00e9n aislados que se incubaron con THC antes de exponerlos al agente lipol\u00edtico hormona adrenocorticotr\u00f3fica (ACTH). Un enfoque complementario in vivo examin\u00f3 los efectos tanto de la privaci\u00f3n de alimentos como de la ACTH sobre los niveles sangu\u00edneos de THC en ratas a las que se hab\u00eda inyectado repetidamente THC (10 mg-kg-1 durante 10 d\u00edas consecutivos. La lip\u00f3lisis promovida por la ACTH o la privaci\u00f3n de alimentos se index\u00f3 mediante la medici\u00f3n de los niveles de glicerol.  <br\/><strong>Resultados clave:<\/strong> La ACTH aument\u00f3 los niveles de THC en el medio de adipocitos pretratados con THC in vitro. La ACTH tambi\u00e9n aument\u00f3 la liberaci\u00f3n de THC de los adipocitos in vitro tomados de ratas pretratadas repetidamente con THC in vivo. Por \u00faltimo, tanto la exposici\u00f3n a ACTH in vivo como la privaci\u00f3n de alimentos durante 24 h aumentaron los niveles de THC y su metabolito, (-)-11-nor-9-carboxi-D9 -tetrahidrocannabinol (THCCOOH) en la sangre de ratas que hab\u00edan sido preexpuestas a repetidas inyecciones de THC.  <br\/><strong>Conclusiones e implicaciones<\/strong>: El presente estudio demuestra que la lip\u00f3lisis aumenta la liberaci\u00f3n de THC de las reservas de grasa de vuelta a la sangre. Esto sugiere la probabilidad de una \u00abreintoxicaci\u00f3n\u00bb por la que la privaci\u00f3n de alimentos o el estr\u00e9s pueden elevar los niveles de THC en sangre en animales expuestos cr\u00f3nicamente a la droga. Habr\u00e1 que seguir investigando para confirmar si esto puede provocar efectos funcionales, como deterioro de la funci\u00f3n cognitiva o \u00abflashbacks\u00bb.<br\/>British Journal of Pharmacology (2009) 158, 1330-1337; doi:10.1111\/j.1476-5381.2009.00399.x; publicado en l\u00ednea el 14 de<br\/>de agosto de 2009  <\/p>\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2782342\/pdf\/bph0158-1330.pdf\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2782342\/pdf\/bph0158-1330.pdf<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reintoxicaci\u00f3n: la liberaci\u00f3n de tetrahidrocannabinol (THC) almacenado en grasa en la sangre espotenciada por la privaci\u00f3n de alimentos o la&#8230;<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"class_list":["post-47202","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - 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