Is Legal Marijuana Making the Opioid Epidemic Worse?

Posted on April 8, 2022 View all news

Is marijuana REALLY a safer alternative to prescription painkillers and the solution to the opioid epidemic? From the beginning, supporters of expanded cannabis legalization have promised that marijuana could save lives by replacing other, more dangerous drugs.

But like so many other claims about marijuana’s supposed benefits, that assertion doesn’t quite hold up. Despite that promise, legal medical and recreational marijuana play a significant role in the still-worsening opioid overdose crisis in America.

Let’s take a closer look at what science and statistics have to say.

What are the Claims?

If you look at almost any pro-marijuana website, there will be statements about how cannabis is an effective treatment for “chronic pain“. Typically, rather than elaborating, these websites then quickly shift focus and talk about benefits other than pain reduction – relief from the nausea and vomiting associated with chemotherapy or the spasticity associated with multiple sclerosis, for example.

Some proponents cite small studies suggesting that patients who use medical marijuana are less likely to use opioid painkillers. Another study supposedly claims that one of the effects of marijuana dispensaries is a significant reduction in the number of opioid-related deaths. Finally, supporters claim that in places where cannabis becomes legal, admissions for opioid use disorder go down.

To get to the truth, we will examine each of these claims, one by one.

What Does the FDA Say?

Would it surprise you to learn that the Food and Drug Administration has not approved medical marijuana as an effective treatment for pain relief? Right off the bat, that weakens the strongest argument put forth by supporters of legalized marijuana expansion.

Vague Wording

The imprecise use of the blanket term “chronic pain“ is misleading. There are many health conditions that can cause or contribute to long-term pain, and there is no magic one-size-fits-all remedy that is effective in all cases, including marijuana.

In fact, even when limited evidence is presented about the supposed pain-relieving benefits of marijuana, it only relates to specific conditions– neuropathic pain or pain due to rheumatic disorders, for example.

Sometimes, it is claimed that marijuana can treat “severe pain“,  but that simply is not true. It is not at all effective at relieving the pain of a broken bone, post-surgical pain, or any other acute condition.

Inconclusive Results

For every study suggesting that marijuana is a suitable pain medication, there is another larger study saying the opposite.

  • 2017: A review of 27 published studies on marijuana and chronic pain found “low strength evidence“ that it relieves nerve pain but does not help with other kinds of persistent pain.
  • 2019: Cannabis showed inconsistent results when treating the pain from rheumatic disorders and neuropathic pain, and was not effective at all at treating chronic cancer pain.
  • 2021: A review of 32 clinical trials found that non-inhaled marijuana had little effect on chronic pain.
Temporary Benefits

It is a fact that opioid-related emergencies do go down in areas where recreational marijuana was recently legalized.

But that positive effect is only temporary.

A 2021 study found that six months after legalization, the number of opioid injuries starts trending upward again, eventually reaching or even surpassing the previous totals. 

Does Marijuana Use Lead to Opioid Abuse?

Getting into the heart of the discussion that medical marijuana helps curb opioid abuse, a 2018 study published in the Journal of Addiction Medicine found that individuals who use medical marijuana have significantly higher rates of both medical and nonmedical use of prescription drugs – including opioid painkillers.

Compared to people who do not use medical marijuana, those that do are more than twice as likely to misuse prescription drugs such as tranquilizers, stimulants, and pain relievers.

A 2012 study by the Yale University School of Medicine found a link between cannabis use and prescription abuse, especially among young adults:

  • Among men aged 18-25, the use of cigarettes, alcohol, or marijuana is associated with an elevated risk of medication misuse.
  • Among women within that age group, however, only marijuana increases the risk of prescription abuse.

According to the Yale study, young adults who smoke weed are two-and-a-half times more likely to misuse prescription medications than their abstaining peers. This is significant, because 80% of heroin addicts started out by abusing prescription opioid painkillers.

Likewise, the National Institute on Drug Abuse reports that people who use marijuana are more than twice as likely to be dependent on or addicted to prescription opioids. They are also six times more likely to take pain pills:

  • At higher-than-recommended dosages
  • For longer periods of time
  • For recreational purposes
  • Without a prescription

A 2020 analysis of data from the National Survey on Drug Use and Health concluded that marijuana use as an adolescent is the most accurate predictor of Opioid Use Disorder in adulthood. 

Worsened Cravings

Another argument used to promote cannabis legalization is the belief that people struggling with Opioid Use Disorder could potentially use marijuana to ease cravings and therefore, be better able to manage their addiction.

But the opposite seems to be true.

One of the biggest dangers of marijuana is how it triggers the use of other drugs. For anyone trying to recover from illicit heroin, prescription pain medications, or synthetic opioids like fentanyl, smoking pot can lead directly to a potentially-fatal relapse.

A study published earlier this year in Emerging Trends in Drugs, Addictions, and Health found that young people with OUD who attempted to use marijuana as a “safer” substitute for their chosen opioid were unsuccessful in their recovery.

Because smoking marijuana actually intensified their cravings for opioids, they were much more likely to relapse into active use.

Actual quotes from participants:

  • “Weed was just not enough, and it accelerated my need for a heroin high.”
  • Smoking weed was like a little tickle, and started the cravings for heroin in motion.”
  • “If I’m already getting high, I might as well get REALLY high, because opiates are better.”
  • “Each time I relapsed on weed, I would immediately think heroin is so much better.”

Yet another study, published in Addiction in 2021 concluded that marijuana actually promotes the use of opioids instead of replacing them.

Study participants who abused opioids were monitored for 90 days. On the days when they smoked weed, the likelihood of them also misusing opioids almost doubled.

This happened even if they were not experiencing physical pain.

The Worst Public Health Crisis in America

If supporters were right, then as more states continue to decriminalize and legalize marijuana use, we should see a corresponding decrease in the number of fatal opioid overdoses.

But opioid deaths are continuing to climb at an alarming rate. According to the Centers for Disease Control and Prevention, there were over 100,000 drug overdose deaths in America during the 12-month period ending in April 2021, a 29% jump from the year before.

75% of those fatal overdoses involved opioids, especially powerful synthetics such as fentanyl and its chemical analogues. In fact, opioid-related deaths spiked 35% within that single year.  

What Do the Experts Say?

Dr. Coleman Drake, Assistant Professor of Health Policy and Management at the University of Pittsburgh, says, “Maybe for those who already have Opioid Use Disorder, they’re finding that cannabis is not sufficient to treat all the symptoms of their condition.”

He continues, “There might be a substitution back towards (heroin, fentanyl, or other opioids) after a period of time.”

Dr. Jodi Gilman, with the Center for Addiction Medicine at Massachusetts General Hospital, says, “There have been many claims about the benefits of medical marijuana for treating pain, insomnia, anxiety, and depression, without sound scientific evidence to support them.”

Dr. Kevin Sabet, formerly the Senior Drug Policy Advisor for the Obama administration and currently the President of Smart Approaches to Marijuana, says this type of scientific research “undercuts the argument that marijuana can be a form of substitute for those suffering from opioid addiction.”

Dr. Sabet continues, saying, “We must not allow industry rhetoric to supersede the preponderance of data we have showing marijuana can potentially exacerbate the addiction crisis our country is suffering.”

The Bottom Line About Marijuana and the Opioid Epidemic

Since 1999, drug overdoses have killed over a million people in this country. To put that in perspective, that is more lives lost than in every battle since World War I combined.

That’s right – drugs have killed more Americans than war.

The overdose crisis is fueled by the opioid epidemic – heroin, prescription painkillers, and now, illicitly-made fentanyl, a drug so powerful that a dose as small as six grains of salt can be fatal. Fentanyl has killed so many people that the CDC now calls it the “deadliest drug in America.”

People who support expanded legalization are quick to point out that “no one has ever fatally overdosed on marijuana”, as if that somehow makes the drug harmless and safe to use.

But marijuana kills in other ways.

Headlines and news stories still mention the ongoing opioid epidemic and how it all started – dishonest and greedy pharmaceutical companies, overprescribing doctors, and shady pill mills.

What has gone woefully unreported, however, is the role that marijuana continues to play as a gateway drug that leads too many people to the harder substances that can ruin and even take their lives.

In other words, the overdose crisis and the opioid epidemic and marijuana expansion are not separate issues. They are all part of a vicious and deadly cycle that affects millions of people.

As a country, we all need to urgently realize that while the overdose crisis is being fueled by the opioid epidemic, that epidemic is in large part fueled by unprecedented marijuana availability and use.

Only then can we take the proper steps needed to break the cycle and save lives.

Every Brain Matters memorializes the lives that we lost due to the marijuana to opioid connection and shares their stories to raise awareness in response to the growing addiction and mental health crisis.

Every Brain Matters is a community of support, advocacy, and science that calls for a cultural change by encouraging the use of the EBM merchandise. Our logo symbolizes “freedom from marijuana and the drug culture expansion.


Is Cannabis being used as a substitute for non‐medical opioids by adults with problem substance use in the United States? A within‐person analysis – Gorfinkel – 2021 – Addiction – Wiley Online Library

Legal weed was supposed to help ease the opioid crisis. What happened? (

Case Reports on the Failure of Smoking Marijuana to Prevent Relapse to Use of Opiates in Adolescents/Young Adults With Opiate Use Disorder – ScienceDirect

Recreational cannabis laws and opioid‐related emergency department visit rates – Drake – – Health Economics – Wiley Online Library

US overdose deaths hit record 93,000 in pandemic last year (

Overdose Deaths Increased by Nearly 30% in 2020 (,as%20Neurontin%2C%20Lyrica%2C%20or%20opiates%20are%20highly%20sedating.

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