Medical Marijuana

Cannabis in Medicine: Evidence Base Approach

The title of “Cannabis in Medicine: An Evidence-Based Approach” contains an irony. In chapter after chapter in this multi-authored book written predominately by providers associated with mainstream medical facilities in Colorado, the authors point out the inadequacy of the evidence we have and the absence of the evidence we need to determine how – or even if – cannabis has medical legitimacy. The foreword’s title, “Losing Ground: The Rise of Cannabis Culture,” sets the tone. David Murray, a senior fellow at the Hudson Institute, argues convincingly that “the current experiment with cannabis, underway nationwide [is] leading us towards a future of unanticipated consequences, a future already established in the patterns of use ‘seeded’ in the population but as yet unmanifested.” In other words, the cannabis horse has not only fled the barn but has been breeding prolifically to the point that we couldn’t get rid of it and its progeny if we wanted to!

Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren’t aware of the facts surrounding cannabis and are guided by public opinion.

This first of its kind book is a comprehensive compilation of multiple facets of cannabis recommendation, use and effects from a variety of different perspectives. Comprised of chapters dedicated to separate fields of medicine, this evidence-based guide outlines the current data, or lack thereof, as well as the need for further study. The book begins with a general overview of the neurobiology and pharmacology of THC and hemp. It then delves into various medical concerns that plague specific disciplines of medicine such as psychiatry, cardiology, gastrointestinal and neurology, among others. The end of the book focuses on non-medical concerns such as public health and safety, driving impairment and legal implications.

Comprised of case studies and meta-analyses, Cannabis in Medicine:  An Evidence-Based Approach provides clinicians with a concise, evidence-based guide to various health concerns related to the use of marijuana. By addressing non-medical concerns, this book is also a useful resource for professionals working in the public health and legal fields.

order book here

Cannabinoid Drug-Drug Interactions
Delta-9-Tetrahydrocannabinol (∆9-THC) & Cannabidiol (CBD) Drug-Drug Interactions

 Although regulatory agency approved prescribing information is often the initial source of information when identifying potential drug-drug interactions, it may only provide for a limited number of exemplars or only reference a class of medications without providing any specific medication examples.  However, with the recent deregulation of CBD oil (hemp oil) and the steady increase in states and countries that have legalized recreational and medical marijuana, these products are often not associated with regulatory agency approved prescribing information.

Penn State College of Medicine, Dept of Pharmacology

 One of the objectives of this website, and associated journal article, is to develop a comprehensive and detailed cannabinoid drug-drug interaction list aligned with regulatory approved prescribing information.  Also, as newer medications are approved, and real-world evidence accumulates, another objective is to routinely update this drug-drug interaction list.

   The following cannabinoid drug-drug interaction information is predicated on regulatory agency approved  cannabinoid manufacturer prescribing information, and then supplemented with the FDA Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers’ online document and the DrugBank database.